Abstract: AIM: To investigate the anti-obesity effect of sibutramine hydrochloride in alimentary obesity rats. METHODS: The alimentary obesity models were established by hyperalimentation for 7 wk in just ablactating SD rats, and then the models were divided into several groups. RESULTS: Sibutramine hydrochloride 9.0, 3.0, and 1.0mg·kg ^-1 ig for 6 wk could significantly decrease body weight, Lee's index, total weight of celiac fat tissue as well as the size of adipocyte, and reduce the level of serum triglyceride in the simple obese rats.But no effect was shown on the density and diameter of jejunum villus. CONCLUSION: Sibutramine hydrochloride is an effective agent of anti-obesity effect in alimentary obesity rats.

Key words: sibutramine hydrochloride, alimentary obesity, rat, weight loss