Abstract: AIM: To observe the clinical effects of ulinasta-tin (UTI) in treatment of patients with acute pancreatitis (AP).METHODS: 102 patients with acute pancreatitis were randomly divided into two groups.There were 51 cases (38 cases of light type, 13 cases of severe type I) in control group, which were given conventional treatment.There were 51 cases (38 cases of light type, 13 cases of severe type I) in treatment group, which were given conventional treatment and UTI.Clinical results were assessed as cured, significant effective, effective and non-effective.RESULTS: The effective rate was 92.1 %in light type, 84.6 % in severe type I in treatment group, while the effective rate was 71.1 % in light type, and 38.5 %in severe type I in control group (P<0.05).The therapeutic effects in treatment group were better than those of in control group (P<0.05) for releasing abdominal distention, amylase, white blood cells and TB.CONCLUSION: UTI is an effective agents in treating AP (light type and severe type I) with fewer side effects.

Key words: ulinastatin, acute pancreatitis, treatment, pharmacodynamics, randomized controlled trial