Recent progress in research of neuroprotective drugs on acute ischemic stroke

Abstract

Abstract: The pathophysiological mechanisms of ischemic cerebral injury involved in the release of excitatory amino acids, depolarization about the infarction, inflammatory reaction and neuron apoptosis.The development and trial of neuroprotective drugs have almost been launched in all links of ischemic cascade reaction.Many neuroprotective drugs were proved to be effective for cerebral ischemia in animal models, but they were not proved on clinical trials.The results and progresses of the preclinical phase and clinical application of various kinds of neuroprotective drugs on the cerebral ischemia were reviewed in this paper and the prospective uses of these drugs were also introduced.

Key words: ischemic stroke, cerebral ischemia, cerebral infarction, neuroprotection, recent progress in research

CLC Number:

R743.31

YU Yue-ping, XU Qiu-qin, WEI Er-qing. Recent progress in research of neuroprotective drugs on acute ischemic stroke[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(8): 841-845.

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