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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2006, Vol. 11 ›› Issue (3): 319-323.

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Effects of resveratrol on isolated coronary artery rings of canine

CHEN Liang, TANG Jian-Hua1, HUANG Huang   

  1. Department of Basic Medicine,Xiangnan University,Chenzhou 423000,Hunan,China;
    1College of Basic Medicine,Central South University,Changsha 410000,Hunan,China
  • Received:2006-02-20 Revised:2006-03-03 Online:2006-03-26 Published:2020-12-04

Abstract: AIM: To investigate the relaxative characteristicsof resveratrol (RES) and 17β-Estradiol (EST)on coronary arteries in dogs and its mechanism.METHODS: Rings of canine coronary arteries were suspended in organ baths containing Krebs-Henseleit solution,and then isometric tension was measured.RESULTS: Both RES and EST caused the does-response contractile curve of KCl in K-H solution and CaCl2 in Ca2+-free K-H solution shift rightward,and their sensitivies and the values of maximum contractions had been decreased.In the Nω-Lnitro-arginine,Methylene Blue and Sodium Orthovanadate groups,the vasorelaxant effects of both estrogens were markedly attenuated (P<0.01),but there was no change in the grouPof Glibenclamide (P>0.05).CONCLUSION: Resveratrol and 17β-Estradiol relaxe vascular smooth muscle in an endothelium-dependent manner,and are not related to KATPchannel.

Key words: resveratrol, 17β-estradiol, coronary artery, vascular tension, endothelium, voltage-dependent calcium channel

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