Keap1-Nrf2-ARE signaling pathway in the chemoprevention of cancer

Abstract

Abstract: Chemoprevention of cancers is still very important since we have not got effective treatments for them.Many natural products (e.g.extracts from plants) or chemical synthetic substances (e.g.additives in foods) were used as chemoprevention regents.Some of them fight the carcinogens or other toxins through induction of the phase 2 antioxidant enzymes.Recently, it is wildly believed that the mechanism of this induction is the activation of Keap1-Nrf2-ARE signaling pathway.Thus understanding of this signaling pathway will widen the field of the cancer research and chemoprevention.

Key words: cancer, chemoprevention, Keap1-Nrf2-ARE signaling pathway

CLC Number:

R73-36⁺2

LIU Xiao-ping. Keap1-Nrf2-ARE signaling pathway in the chemoprevention of cancer[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(6): 716-720.

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