Abstract: AIM: To investigate the protective effect of a new type nerves protectant TQ0701-2, as the derivate of edaravone free radical scavenger, on cerebral ischemia reperfusion injury rat.METHODS: 120 male SD rats were randomly divided into sham group, model group, edaravone group (3.0 mg/kg) and TQ0701-2 highdose group (6.0 mg/kg), middle-dose (3.0 mg/kg) and low-do segroup (1.5mg/kg).Animals in the latter five groups were subjected to transient focal ischemia by the middle cerebral artery occlusion (MCAO) for 2 h before reperfusion, while the sham group wasn't ischemic.The rats were injected with edaravone or TQ0701-230 min before ischemic and 0 min, 2 h after reperfusion in edarav one and TQ0701-2 groups, sham group and model group were treated with normal saline as well. After 24 h of reperfusion, the infarct ratio, neurological and histological deficient and the changes of pathohistology were evaluated.RESULTS: The infarct ratios and neurological deficit scores in the model group were increased (P <0.01 vs. sham group).The neuro logical deficit scores and infarct ratios in three doses of TQ0701-2 were significantly decreased (P <0.01vs.model group), similar to edaravone, and the protection was enhanced in a dose-dependent manner.Moreover, TQ0701-2 improved neuronal degeneration and necrosis induced by ischemia reperfusion.CONCLUSION: Thesere sults show that the the derivate of edaravone TQ 0701-2 has notable protective effect on cerebral ischemia reperfusion injury in rats.

Key words: TQ0701-2, Cerebral ischemia reperfusion, Edarav one, Protection