Abstract: AIM: To invest igate the therapeutic protective effects and function regulations of conventional antidiabe tictreatment plus piperazine ferulate tablet on trauma ticvascular endothelial cells in type 2 diabetes mellitus.METHODS: 80 patients were randomly divided into the treating group (n =37)and the control group (n=43).Conventional antidiabetictreatment plus piperazine ferulate was given to the treating group, and the control group was treated with convent ional antidiabetic treatment plus vitamin Cevery day, and all the patients were treated with 4 weeks.The levels of fast in gblood glucose (FBG), glycosylated hemoglobin alC(HbalC), circulating endothelial cell(CEC), serum lipid peroxide(LPO), endothelin(ET)、nitricoxide (NO), tissue-plasminogen activator (t-PA)were determined during the therapeutic period.RESULTS: After 4 weeks of treatment, the levels of serum CEC, LPO and ET were lower in the treating group than those in the control group (P <0.01).while the levels of NO and t-PA were higher in the treating group than those in the control group (P <0.01), there was significant difference between the two groups(P <0.01).CONCLUSION: Combination of conventional antidiabet ictreatment and piperazine ferulate can pro tect vascular endo thelial cells and regulate their functione from the damage in type 2 diabetes mellitus.

Key words: Piperazine ferulate, Type 2 diabetes mellitus, Endothelial cell