Progress in sleep-wake regulation of dopamine D2 receptor

Abstract

Abstract: Dopamine (DA) modulates diverse wake-related behaviors including movement, reward, and cognition. Dopaminergic neurons are located in the substantia nigra pars compacta and ventral tegmental area. There are five distinct DA receptors (R): D₁R, D₂R (D_2SR and D_2LR), D₃R, D₄R and D₅R in the central nervous system, in which D₁R and D₂R are majorly expressed. The affinity of D₂R for endogenous DA is significantly higher than that of D₁R. Recently, studies by pharmacological and gene knock-out animals revealed that dopamine D₂R is essential inmaintaining wakefulness. Here, we review the progress on roles of D₂R in sleep-wake regulation.

Key words: Dopamine, D₂ receptor, Knockout mice, Sleep, Wake

CLC Number:

XU Qi, QU Wei-min, HUANG Zhi-li. Progress in sleep-wake regulation of dopamine D₂ receptor[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(4): 361-366.

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Progress in sleep-wake regulation of dopamine D₂ receptor

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