Abstract: AIM: To observe the curative effect and safety of Budesonide inhalation suspension (BIS) in maintenance therapy of patients with severe persistent asthma .METHODS: 24 patients with severe asthma were screened,the patients enrolled were treated with BIS 2 mg twice a day and salbutamol aerosol as need for 8 weeks. The curative effect outcomes after 4 treating weeks and 8 treating weeks, including pulmonary function test (FEV₁), asthma symptom scores,salbutamol aerosol use, as well as the side effects index at the end of study, such as urocortisol level, were collected and compared before study(baseline).RESULTS: 21 patients were successfully enrolled,20 of which completed the treatment. The curative effect outcomes were improved compared with the baseline(P<0.05), FEV₁ was improved by 12.7% and 13.7%, daytime symptom scores were improved by 31.3% and 29.8%, night symptom scores were improved by 32.8% and 36.8%, times of Ventolin daily use were reduced by 39.1% and 41.2% after 4 weeks treatment and 8 weeks treatment respectively. After 8 weeks treatment, urocortisol in all patients was normal range and no severe side effect occurred.CONCLUSION: BIS has good curative effect and safety in treating patients with severe persistent asthma as maintenance therapy.

Key words: Budesonide inhalation suspension, severe persistent asthma, therapy, pulmonary function test, score