Curcumin alleviate intrapulmonary inflammation in rat experimental hepatopulmonary syndrome

Abstract

Abstract:

AIM: To evaluate the protective effect of curcumin in an experimental model of hepatopulmonary syndrome (HPS) induced by bile duct ligation in rats. METHODS: One week after surgery, curcumin (50 mg·kg^-1·d^-1) was administered intragastrically for two weeks. Arterial blood gas analysis was performed. Plasma TNF-α and ALT level was measured. Pathological change in rat lung tissue and liver tissue were observed through HE staining. CD68, TNF-α and NF-κB P-65 were detected by immunofluorescence, and IκBα/p-IκBα was assessed by Western blotting. RESULTS: Curcumin alleviated lung tissue and pulmonary intravascular monocyte accumulation and significantly decreased AaPO. Also, pulmonary TNF-α level and lung tissue NF-κB activity were reduced. CONCLUSION: Curcumin can protect HPS rat from pulmonary inflammation injury. The mechanism may be related with anti-inflammation by inhibition of TNF-α/NF-κB.

Key words: hepatopulmonary syndrome, curcumin, TNF-α, NF-κB

CLC Number:

R965.2

LI Xujiong, LIU An, CHEN Yunxia, LI Shufen. Curcumin alleviate intrapulmonary inflammation in rat experimental hepatopulmonary syndrome[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(7): 738-742.

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