Protective effects of cilostazol on the chronic ischemic brain injury in mice and its action mechanism

Abstract

Abstract: AIM: To observe the protective effects of cilostazol on chronic ischemic brain injury in mice and the relationship to angiogenesis. METHODS: Focal cerebral ischemia was induced by middle cerebral artery occlusion (MCAO). Cilostazol (10 mg/kg) was i.p. injected at 1, 4, 7 h and 1-14 d once a day after ischemia. The neurological deficits, angle in inclined board test, infarct volume, neuron density, and the expressions of VEGF and Flk-1 in ischemic region were determined at the 35 d after ischemia. RESULTS: Cilostazol (10 mg/kg) significantly reduced the neurological deficits and infarct volume, and increased the angle in inclined board test, the neuron density, and the expressions of VEGF and Flk-1. CONCLUSION: Cilostazol has neuroprotective effect on chronic ischemic brain injury in mice, which may relate to angiogenesis via inducing the expressions of VEGF and Flk-1.

Key words: Cilostazol, Vascular endothelial growth factor (VEGF), Vascular endothelial growth factor receptor 2 (Flk-1), Cerebral ischemia

CLC Number:

R965.2

YE Yi-lu, ZHANG Qi, ZHANG Jian-ting, ZHANG Xiao-hua, YU Yue-ping, WEI Er-qing. Protective effects of cilostazol on the chronic ischemic brain injury in mice and its action mechanism[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(2): 130-134.

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