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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2005, Vol. 10 ›› Issue (2): 141-144.

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Effects of antioxidant ebselen (PZ51) on eNOS protein expression of coronary artery in SHRsp

SUI Hui, WANG Wen, WANG Pei-he, LI Yue   

  1. Institute of Cardiovascular, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China
  • Received:2004-12-08 Revised:2005-01-27 Online:2005-02-06 Published:2020-11-18

Abstract: AIM: To investigate the effects of new antioxidant, seleno-Glutathione peroxidase PZ51 on endothelial nitric oxide synthase (eNOS) protein expression of coronary artery in Stroke-Prone Spontaneously Hypertensive rat (SHRsp) during the chronic process of hypertension.METHODS: 22 SHRsp of 8-week-old which were randomly divided into PZ51 group and control group were administered by gavage for six weeks.Heart weight ratio, heart structure, the level of nitric oxide (NO) of myocardium and eNOS protein of coronary artery was examined. RESULTS: Compared with the control group, PZ51 significantly increased NO of myocardium homogenate (1.18±0.25 vs 0.72±0.18 μmol°mg-1 prot, P<0.05) and eNOS protein expression (7.45±2.10 vs 2.77±2.07, P<0.05) of coronary artery.CONCLUSION: After 6 weeks administration of PZ51, the eNOS protein expression of coronary artery and NO level of myocardium in SHRsp significantly increased.

Key words: PZ51, SHRsp, endothelial nitric oxidesynthase, coron aryartery

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