Abstract: Objective To know the vitamin A and E level changes and its clinical significance in children of different ages with recurrent respiratory tract infections,and provide reference for disease prevention. Methods A total of 130 cases with recurrent respiratory tract infection(RRTI group) and 124 health children (control group) were selected from April 2015 to June 2016 in the Affiliated Hospital of Weifang Medical University.All children were divided into 0~1,1~3,3~6 and > 6 years old groups.Serum vitamin A,E levels were determined by high performance liquid chromatography (HPLC). Results The levels of vitamin A and E in RRTI group were lower than those in the control group (P<0.05).The level of vitamin A was the lowest in the 0~1 year old children,but there was no significant difference in vitamin E levels among all age groups(P>0.05). Conclusions Low levels of vitamin A and E are associated with recurrent respiratory infections.Both recurrent respiratory tract infection and health examination,0~1 year-old children were the lowest level of vitamin A,followed by >6 years old group;And vitamin E levels are in the normal range,and no significant difference in all ages.

Key words: recurrent respiratory tract infections, different ages groups, vitamin A, vitamin E, children

摘要： 目的 了解不同年龄反复呼吸道感染儿童体内维生素A、E水平及临床意义,为疾病预防提供参考。方法 选取2015年4月-2016年6月在潍坊医学院附属医院就诊的反复呼吸道感染儿童130例,健康儿童124例(对照组),按年龄分为0~1、1~3、3~6岁及>6岁四组,采用高效液相色谱法(HPLC)对其血清维生素A、E水平进行测定。结果 感染组儿童血清维生素A、E水平均低于对照组(P<0.05);无论感染组还是对照组,0~1岁组儿童体内维生素A水平最低,其次为>6岁组儿童(P<0.05),但各年龄组间维生素E水平差异无统计学意义(P>0.05)。结论 维生素A、E水平低与反复呼吸道感染有关;无论是反复呼吸道感染还是健康查体,0~1岁儿童体内维生素A水平最低,其次为>6岁组;而维生素E水平均在正常范围内,且在各年龄段无明显差异。

关键词: 反复呼吸道感染, 不同年龄组, 维生素A, 维生素E, 儿童