Abstract: Objective To investigate the influential factors of Down's syndrome and to provide evidences for prevention. Methods A case-control study was conducted among children with or without Down's syndrome at Children's Hospital of Xuzhou,from January 2012 to December 2013.Parents of cases with Down's syndrome and controls were asked to fill in a questionnaire. Results Logistic analysis showed that Down's syndrome was associated with advanced maternal age(≥35 years old)(OR=5.55),maternal pre-pregnancy fever (OR=7.87),exposure to pesticides (OR=12.90),the surrounding environmental pollution (OR=6.94),decoration or purchasing new furniture or a new car (OR=6.85),maternal manicure (OR=44.58). Conclusions Down's syndrome is affected by multiple factors.Risk factors for Down's syndrome will include advanced maternal age(≥35 years old),maternal pre-pregnancy fever,exposure to pesticides,the surrounding environmental pollution,decoration or purchasing new furniture or a new car,maternal manicure.

Key words: Down's syndrome, case-control study, influential factors

摘要： 目的 分析唐氏综合征发生的影响因素,为制定干预措施提供参考依据。方法 采用成组病例对照研究,对2012年1月-2013年12月在徐州市儿童医院病理科经染色体检查被确诊为唐氏综合征的患儿父母及同时间就诊且年龄相差不超过5个月的正常儿童的父母进行问卷调查。结果 多因素Logistic回归分析显示,母亲育龄(≥35岁)(OR=5.55)、母亲孕前发热(OR=7.87)、接触农药(OR=12.90)、周围环境污染(OR=6.94)、家庭装修或购买新家具及新车(OR=6.85)、母亲美甲(OR=44.58)与唐氏综合征的发生有关。结论 唐氏综合征的影响因素复杂多样,其中母亲育龄(≥35岁)、孕前发热、接触农药、周围环境污染、家庭装修或购买新家具及新车、母亲美甲是唐氏综合征的危险因素。

关键词: 唐氏综合征, 病例对照研究, 影响因素