Abstract: Aim The effect of China-produced zopiclone and imported zo piclone in amygdala kindled rats were compared.Methods Amygdala kindling model was built in female wistarrats.The kindled rats were given orally china-produced and imported zopiclone in the doses of 1.5, 3 and 5 mg · kg^-1 or veicle (1.25 %mucilag ot ragacanthae), respectively. SeizuReseverity and after discharge duration were oberved before and 30 minutes after adminstration.Result Both china-produced and imported zopiclone weakened the seizuReseverity and decreased the after discharge duration in doses of 3and 5 mg · kg^-1 notably. There was a significant difference between before and after drug treatment (P<0.01), but there was not a significant difference between two drugs at 3 and 5 mg · kg^-1 doses(P>0.05).Conclusion Both china-produced and imported zopiclones inhibited kindled seizures.The intensity of two drugs are equal basically.

Key words: china-produced zopiclone, imported zopiclone, amgdala-kinded, rat