Clinical study of protection and treatment of leech compound eye drops on senile cataract by the lens opacities classification system Ⅲ

Abstract

Abstract: AIM: To investigate the protection and treatment of compound leech (Co-SZ) eye drops on senile cataract by the lens opacities classification system Ⅲ (LOCS Ⅲ).METHODS: Co-SZ eye drops were compounded by adding composition full of zinc and vitamin C to SZ eye drops.Pirenoxine sodium eye drops of imported agent were set as control.The protection and treatment of two eye drops on senile cataract were observed and compared by LOCS Ⅲ.RESULTS: The improve rate (76 %) of vision, letdown rate (59 %) of lens opacities and efficiency (66 %) in Co-SZ eye drops group were significantly higher than those in pirenoxine sodium eye drops group (2.0 %, 0.0 % and 2.0 %).CONCLUSION: Co-SZ eye drops is a safe and effective anti-cataract agent.

Key words: senile cataract, Chinese medicine, leech, zinc, vitamin C, eye drops, prevention, treatment, lens opacities classification system

CLC Number:

HUANG Xiu-Rong, QI Ming-Xin, ZHANG Song-Qing, CHEN Sheng, KE Fa-Jie, PAN Jie. Clinical study of protection and treatment of leech compound eye drops on senile cataract by the lens opacities classification system Ⅲ[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(1): 63-66.

References

1 黄秀榕, 祁明信, 汪朝阳, 等.SZ 滴眼液防治半乳糖白内障的实验研究[J]. 眼科研究, 2001;19:220-3
2 黄秀榕, 祁明信.复方SZ 滴眼液对实验性半乳糖白内障的防治作用[J]. 中国病理生理学杂志, 2002;18:1206-8
3 赵加良.晶状体病[A]. 见:惠延年, 主编.眼科学[M]. 第5版.北京:人民卫生出版社, 2001:99-100
4 Chylack Jr LT,Wolfe JK, Singer DM, et al. The lens opacities classification system Ⅲ[J]. Arch Ophthalmol, 1993;111:831-6
5 殷悦, 吴静安, 晏晓明, 等.谷胱甘肽滴眼剂临床研究[J]. 中国临床药理学杂志, 2000;16:179-81
6 徐兆山.水蛭的临床应用[J]. 中医药学报, 1990;11:38-41
7 黄雪梅.水蛭的实验和临床研究概况[J]. 湖南中医学院学报, 1997;17:74-7
8 Kim DR, Kang KW.Amino acid sequence of piguamerin, an antistasin-type protease inhibitor from the blood sucking leach hirudo nipponia[J]. Eur J Biochem, 1998;254:692-7
9 郭文菊, 李长安.SZ 的氨基酸及微量元素分析[J]. 中医药研究, 1997;13;46-9
10 颜世铭, 洪昭毅, 李增禧.实用元素医学[M]. 郑州:河南医科大学出版社, 1999:107-8
11 Fabe JS, Grahn BH, Paterson PG.Zinc concentration of selected ocular tissues in zincdeficient rats[J]. Biol Trace Elem Res, 2000;75:43-52
12 Behndig A, Karlsson K, Reaume AG, SentmanML, Marklund SL.In vitro photochemical cataract in mice lacking copper-zinc superoxide dismutase[J]. Free Radic Biol Med, 2001;15;31:738-44
13 Egener A, Heinitz M, Dwinger M.Experimental evidence for interactive effects of chronic UV irradiation and nutritional deficiencies in the lens[J]. Dev Ophthalmol, 2002;35:113-24
14 Sackett CS, Schenning S.The age-related eye disease study: the results of the clinical trial[J]. Insight, 2002;27:5-7
15 Age-Related Eye Disease Study Research Group.The age-related eye disease study:a clinical trial of zinc and antioxidants-age-related eye disease study report No2[J]. J Nutr, 2000;130:1516-9
16 商福.抗白内障药物研究的现状与展望[J]. 国外医学眼科学分册, 1991;100-3

[1]	FU Xiaoyu, KONG Deguang, LI Juanjuan. Treatment progress of triple positive breast cancer [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(8): 866-875.
[2]	WANG Chaoyi, SONG Qiang, XIONG Xin, WANG Mengyuan. Research progress on diagnosis and treatment of granulomatous lobular mastitis [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(8): 910-917.
[3]	QIAO Hongliang, DING Ning, DENG Kaihong, LIU Binbin, DONG Chuanjiang, CHEN Xiaobo, ZOU Lili. New progress in research on novel control strategies for methicillin-resistant staphylococcus aureus infection [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(6): 676-687.
[4]	HU Kangyi, CAO Linzhong, WAN Chaochao, SHANG Zhengya, YANG Xiaorui, ZHANG Yongjie. Research progress of traditional Chinese medicine regulating mitochondrial function in the treatment of steroid-induced femoral head necrosis [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(6): 688-696.
[5]	QIN Wenxiu, XU Junfeng, YANG Ting, WANG Pingfei. Research progress on signaling pathway of tanshinoneIIA in treatment of nerve injury after ischemic stroke [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(6): 705-713.
[6]	WANG Juan, LIU Weiying, YE Yucai, FU Wenli, ZHANG Sha, LI Leping. Research progress of norepinephrine reuptake inhibitor combined with antimuscarinic in the treatment of obstructive sleep apnea [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(6): 714-720.
[7]	LI Yanyang, WANG Yunjiao, LV Shichao. Effects and mechanism of traditional Chinese medicine injection in prevention and treatment of cardiotoxicity induced by antineoplastic drugs [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(5): 572-577.
[8]	LI Shuang, HAN Shuzhen, DAI Yuting, XIU Minghui, DU Xianqin, HE Jianzheng, LIN Xingyao. Progress in the prevention and treatment of traditional Chinese medicine based on the mechanism of intestinal injury of various chemotherapy [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(5): 583-593.
[9]	TAO Yijia, YANG Chun, LIU Cunming . Progress in clinical application of topical anesthesia [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(5): 594-600.
[10]	QI Xiaofeng, LUO Yali, XIAO Mengyong, ZHOU Shiqin, ZHOU Wen, AN Fangyu, WEI Benjun, LIU Yongqi. Research status of dialectical prevention and treatment of acute lung injury based on the theory of "Wei qi and Ying Xue" [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(4): 429-437.
[11]	ZHANG Li, LIN Xingyao, SHANG Yun, WANG Qiang. Progress on the pathological mechanism and treatment of frostbite [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(3): 347-354.
[12]	DANG Yangbin, LIANG Yuxin, WANG Tiancheng. Research progress on the related treatment of progressive myoclonic epilepsy [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(10): 1184-1194.
[13]	JIA Tao, TENG Jinliang. New narcotic analgesics: esketamine [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(7): 834-840.
[14]	ZENG Xiaofan, XU Yiqi, LIU Shu, WU Qian, LI Zibao, HE Junjun, JIN Yuelong, ZHAO Yongli, HE Chunling, GAO Jialin. Retrospectively analysis of the effect of low-dose aspirin on primary prevention of non-fatal myocardial infarction and cerebral infarction in patients with type 2 diabetes mellitus [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(6): 665-671.
[15]	DING Hao, GAO Zhenhua, ZHENG Yun. Research progress of microRNA in diagnosis and treatment of prostate cancer [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(6): 696-708.