Effects of maslinic acid as a novel glycogen phosphorylase inhibitor on cerebral ischemia in mice

Abstract

Abstract: AIM: This experiment was designed to study the protective effects of maslinic acid, a novel glycogen phosphorylase inhibitor, on cerebral ischemia in mice. METHODS: The model of acute cerebral ischemia-reperfusion in mice was set up by ligating bilateral common carotid artery and vagus, thus blocking the blood stream for 90 s, and subjecting mice to 5 min reperfusion.Brain samples were prepared to observe the cerebral injury;liver samples were prepared to observe the status of hepatic glucose metabolism, which contribute to the observed hyperglycemia during cerebral ischemia. RESULTS: Maslinic acid significantly reduced the lactate and MDA level, increased SOD and LDH activity and preserved the hepatic glycogen after mice were subjected to acute cerebral ischemia-reperfusion. CONCLUSION: Maslinic acid may exert its potential protective effects against cerebral ischemic injury, at least in part, through inhibition of over degradation of cerebral glycogen and thus reducing/Lactate production during ischemia.

Key words: cerebral ischemia, ischemia-reperfusion injury, lactate acidosis, glycogen phosphorylase inhibitors, maslinic acid

CLC Number:

R965.1

GUAN Teng, LI Yun-man, SUN Hong-bin. Effects of maslinic acid as a novel glycogen phosphorylase inhibitor on cerebral ischemia in mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(4): 381-384.

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