Recent progress in research of protective effects of erythropoietin on cerebral ischemia

Abstract

Abstract: It has been proved that erythropoietin has neuroprotective effect and therapeutic action on cerebral ischemia in vivo and in vitro. The mechanisms of these actions may be involved in anti-exitotoxicity of aminoglutaric acid, regulating the synthesis of nitric oxide, antioxidation, antiinflammatory, inhibiting neuron apoptosis, accelerating angiogenesis, neurogenesis, neurotrophy and others. In addition, exogenous erythropoietin can enter brain tissue through blood-brain barrier and exert neuroprotection. So it is indicated that erythropoietin can be expected to be a new drug to prevent and treat cerebral ischemia.

Key words: erythropoietin, cerebral ischemia, neuroprotection

CLC Number:

R743. 34

YU Yue-ping, YE Yi-lu. Recent progress in research of protective effects of erythropoietin on cerebral ischemia[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(6): 609-613.

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