Significance of ERK/MAPK signal transduction pathway in the targeting treatment of gastrointestinal cancer

Abstract

Abstract: Extracellular signal-regulated kinase mitogen-activated protein kinase (ERK/MAPK) signaling pathway plays an important role in gastrointestinal tumorigenesis and development.ERK/MAPK signal transduction pathway has three important molecular targets:the small G protein Ras, Raf kinase andMEK1/2 and ERK1/2.At present, there are three kinds of approach which can inhibit ERK/MAPK signal transduction pathway:⑴ destroying the structure and (or) function of the target protein, ⑵adopting the deficit strategy, ⑶damaging the interaction between proteins. These approaches can provide new ideas for the treatment of gastrointestinal cancer.

Key words: ERK/MAPK, signal transduction, gastroenteric tumor, inhibitor, therapy

CLC Number:

R735

HUANG Jian-xiong, WU Pei. Significance of ERK/MAPK signal transduction pathway in the targeting treatment of gastrointestinal cancer[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(7): 833-836.

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