Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2014, Vol. 19 ›› Issue (3): 334-340.
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YAO Wei-feng1,2,3, ZHOU Li-na1,3, ZHANG Li1,3, DING An-wei1,3, LI Wei1
Received:
2013-04-20
Revised:
2014-02-25
Online:
2014-03-26
Published:
2014-04-10
CLC Number:
YAO Wei-feng, ZHOU Li-na, ZHANG Li, DING An-wei, LI Wei. Cell Metabonomics and its Applications[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(3): 334-340.
[1] Nicholson JK, Lindon JC, Holmes E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data[J]. Xenobiotica, 1999, 29(11): 1181-1189. [2] Cortés M, Pareja E, Castell JV, et al. Exploring mass spectrometry suitability to examine human liver graft metabonomic profiles[J]. Transplant Proc, 2010, 42(8): 2953-2958. [3] García-Cañaveras JC, Donato MT, Castell JV, et al. A comprehensive untargeted metabonomic analysis of human steatotic liver tissue by RP and HILIC chromatography coupled to mass spectrometry reveals important metabolic alterations[J]. J Proteome Res, 2011, 10(10): 4825-4834. [4] Fiehn O. Metabolomics the link between genotypes and phenotypes[J]. Plant Mol Biol, 2002, 48: (1/2):155-171. [5] Wang TJ, Larson MG, Vasan RS, et al. Metabolite profiles and the risk of developing diabetes[J]. Nat Med, 2011, 17(4): 448-453. [6] Wang X, Zhang A, Han Y, et al. Urine metabolomics analysis for biomarker discovery and detection of jaundice syndrome in patients with liver disease[J]. Mol Cell Proteomics, 2012, 11(8): 370-380. [7] Cuperlovic-Culf M, Barnett DA, Culf AS, et al. Cell culture metabolomics: applications and future directions[J]. Drug Discov Today, 2010, 15(15/16): 610-621. [8] Chen R, Mias GI, Li-Pook-Than J, et al. Personal omics profiling reveals dynamic molecular and medical phenotypes[J]. Cell, 2012, 148(6): 1293-1307. [9] West PR, Weir AM, Smith AM, et al. Predicting human developmental toxicity of pharmaceuticals using human embryonic stem cells and metabolomics[J]. Toxicol Appl Pharmacol, 2010, 247(1): 18-27. [10] Bai J, Wang MX, Chowbay B, et al. Metabolic profiling of HepG2 cells incubated with S(-) and R(+) enantiomers of anti-coagulating drug warfarin[J]. Metabolomics, 2011, 7(3): 353-362. [11] McNamara LE, Sjöström T, Meek RM, et al. Metabolomics: a valuable tool for stem cell monitoring in regenerative medicine[J]. J R Soc Interface, 2012, 9(73): 1713-1724. [12] Bayet-Robert M, Morvan D, Chollet P, et al. Pharmacometabolomics of docetaxel-treated human MCF7 breast cancer cells provides evidence of varying cellular responses at high and low doses[J]. Breast Cancer Res Treat, 2010, 120(3): 613-626. [13] Chong WP, Thng SH, Hiu AP, et al. LC-MS-based metabolic characterization of high monoclonal antibody-producing Chinese hamster ovary cells[J]. Biotechnol Bioeng, 2012, 109(12): 3103-3111. [14] Valdés A, Simó C, Ibáñez C, et al. Effect of dietary polyphenols on K562 leukemia cells: a Foodomics approach[J]. Electrophoresis, 2012, 33(15): 2314-2327. [15] Van Gulik WM, Canelas AB, Taymaz-Nikerel H, et al. Fast sampling of the cellular metabolome[J]. Methods Mol Biol, 2012, 881: 279-306. [16] Wittmann C, Kromer JO, Kiefer P, et al. Impact of the cold shock phenomenon on quantification of intracellular metabolites in bacteria[J]. Anal Biochem, 2004, 327(1): 135-139. [17] Wiendahl C, Brandner JJ, Kuppers C, et al. A microstructure heat exchanger for quenching the metabolism of mammalian cells[J]. Chem Eng Technol, 2007, 30: 322-328. [18] Sellick CA, Hansen R, Maqsood AR, et al. Effective quenching processes for physiologically valid metabolite profiling of suspension cultured mammalian cells[J]. Anal Chem, 2009, 81(1): 174-183. [19] Dietmair S, Timmins NE, Gray PP, et al. Towards quantitative metabolomics of mammalian cells: Development of a metabolite extraction protocol[J]. Anal Biochem, 2010, 404(2): 155-164. [20] Koǐínek M, Sístek V, Mládková J, et al. Quantification of homocysteine-related metabolites and the role of betaine-homocysteine S-methyltransferase in HepG2 cells[J]. Biomed Chromatogr, 2013, 27(1): 111-121. [21] Álvarez-Sánchez B, Priego-Capote F, Luque de Castro MD. Metabolomics analysis II. Preparation of biological samples prior to detection[J]. TrAC Trends in Analytical Chemistry, 2010, 29(2): 120-127. [22] Chrysanthopoulos PK, Goudar CT, Klapa MI. Metabolomics for high-resolution monitoring of the cellular physiological state in cell culture engineering[J]. Metab Eng, 2010, 12(3): 212-222. [23] Sellick CA, Knight D, Croxford AS, et al. Evaluation of extraction processes for intracellular metabolite profiling of mammalian cells: matching extraction approaches to cell type and metabolite targets[J]. Metabolomics, 2010, 6: 427-438. [24] Danielsson AP, Moritz T, Mulder H, et al. Development and optimization of a metabolomic method for analysis of adherent cell cultures[J]. Anal Biochem, 2010, 404(1): 30-39. [25] Lorenz MA, Burant CF, Kennedy RT. Reducing time and increasing sensitivity in sample preparation for adherent mammalian cell metabolomics[J]. Anal Chem, 2011, 83(9): 3406-3414. [26] Haynes CA, Allegood JC, Sims K, et al. Quantitation of fatty acyl-coenzyme As in mammalian cells by liquid chromatography-electrospray ionization tandem mass spectrometry[J]. J Lipid Res, 2008, 49(5): 1113-1125. [27] Cao B, Aa J, Wang G, et al. GC-TOFMS analysis of metabolites in adherent MDCK cells and a novel strategy for identifying intracellular metabolic markers for use as cell amount indicators in data normalization[J]. Anal Bioanal Chem, 2011, 400(9): 2983-2993. [28] Sheikh KD, Khanna S, Byers SW, et al. Small molecule metabolite extraction strategy for improving LC/MS detection of cancer cell metabolome[J]. J Biomol Tech, 2011, 22(1): 1-4. [29] Faijes M, Mars AE, Smid EJ. Comparison of quenching and extraction methodologies for metabolome analysis of Lactobacillus plantarum[J]. Microb Cell Fact, 2007, 6: 27. [30] Rooney OM, Troke J, Nicholson JK, et al. High - resolution diffusion and relaxation- edited magic angle spinning 1H NMR spectroscopy of intact liver tissue[J]. Magn Reson Med, 2003, 50(5): 925-930. [31] Ippolito JE, Merritt ME, Backehed F, et al. Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers[J]. Proc Natl Acad Sci USA, 2006, 103(33): 12505-12510. [32] Ketola RA, Mauriala T. Mass spectrometric tools for cell and tissue studies[J]. Eur J Pharm Sci, 2012, 46(5): 293-314. [33] Ruiz-Aracama A, Peijnenburg A, Kleinjans J, et al. An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzop-dioxin[J]. BMC Genomics, 2011, 12: 251. [34] Suh JH, Kim RY, Lee DS. A new metabolomic assay to examine inflammation and redox pathways following LPS challenge[J]. J Inflamm (Lond), 2012, 9(1): 37. [35] Fan TW, Lane AN. NMR-based stable isotope resolved metabolomics in systems biochemistry[J]. J Biomol NMR, 2011, 49(3/4): 267-280. [36] Patterson AD, Li H, Eichler GS, et al. UPLC-ESI-TOFMS-Based Metabolomics and Gene Expression Dynamics Inspector Self-Organizing Metabolomic Maps as Tools for Understanding the Cellular Response to lonizing Radiation[J]. Anal Chem, 2008, 80(3): 665-674. [37] Kao YY, Liu KT, Huang MF, et al. Analysis of amino acids and biogenic amines in breast cancer cells by capillary electrophoresis using polymer solutions containing sodium dodecyl sulfate[J]. J Chromatogr A, 2010, 1217(4): 582-587. [38] Wang Y, Gao D, Chen Z, et al. Acridone Derivative 8a induces Oxidative Stress-Mediated Apoptosis in CCRF-CEM Leukemia Cells: Application of Metabolomics in Mechanistic Studies of Antitumor Agents[J]. PLOS ONE, 2013, 8(5): e3572. [39] Martínez-Martín N, Blas-García A, Morales JM, et al. Metabolomics of the effect of AMPK activation by AICAR on human umbilical vein endothelial cells[J]. Int J Mol Med, 2012, 29(1): 88-94. [40] Zhang L, Wang L, Hu Y, et al. Selective metabolic effects of gold nanorods on normal and cancer cells and their application in anticancer drug screening[J]. Biomaterials, 2013, 34(29): 7117-7126. [41] MacIntyre DA, Melguizo Sanchís D, Jiménez B, et al. Characterisation of Human Embryonic Stem Cells Conditioning Media by 1H-Nuclear Magnetic Resonance Spectroscopy[J]. PLOS ONE, 2011, 6(2): e16732. [42] Le A, Lane AN, Hamaker M, et al. Glucose-independent glutamine metabolism via TCAcycling for proliferation and survival in B-cells[J]. Cell Metab, 2012, 15(1): 110-121. [43] Tomita M, Kami K. Cancer. Systems biology, metabolomics, and cancer metabolism[J]. Science, 2012, 336(6084): 990-991. [44] Peng S, Yan L, Zhang J, et al. Hepatotoxicity of perfluorooctanoic acid in human hepatocytes using metabonomics[J]. Se Pu, 2012, 30(2): 123-127. [45] Yanes O, Clark J, Wong DM, et al. Metabolic oxidation regulates embryonic stem cell differentiation[J]. Nat Chem Biol, 2010, 6(6): 411-417. [46] Lemons JM, Feng XJ, Bennett BD, et al. Quiescent Fibroblasts Exhibit High Metabolic Activity[J]. PLOS Biol, 2010, 8(10): e1000514. [47] Van Ravenzwaay B, Cunha GC, Leibold E, et al. The use of metabolomics for the discovery of new biomarkers of effect[J]. Toxicol Lett, 2007, 172(1/2): 21-28. [48] Lindon JC, Holmes E, Bollard ME, et al. Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis[J]. Biomarkers, 2004, 9(1): 1-31. [49] Klawitter J, Shokati T, Moll V, et al. Effects of lovastatin on breast cancer calls: a proteo-metabonomic study[J]. Breast Cancer Res, 2010, 12(2): R16. [50] Bordbar A, Mo ML, Nakayasu ES, et al. Model-driven multi-omic data analysis elucidates metabolic immunomodulators of macrophage activation[J]. Mol Syst Biol, 2012, 8: 558. [51] Jennen D, Ruiz-Aracama A, Magkoufopoulou C, et al. Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells[J]. BMC Syst Biol, 2011, 5: 139. [52] Peng S, Yan L, Zhang J, et al. An integrated metabonomics and transcriptomics approach to understanding metabolic pathway disturbance induced by perfluorooctanoic acid[J]. J Pharm Biomed Anal, 2013, 86C: 56-64. |
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