Effects of traditional Chinese medicine on the role of warfarin and the mechanisms

Abstract

Abstract: Warfarin is an oral coumarin anticoagulants which has been commonly used in clinic for anticoagulant therapy, with high protein binding rate, relying on the cytochrome P450 enzyme metabolism, and with narrow therapeutic window, etc.. It easily interacts with other drugs, resulting in serious consequences, such as increased bleeding risk or inadequate anticoagulant therapy. Traditional Chinese medicine has been widely used in the treatment of cardiovascular diseases with unique advantages, and has more opportunities to be coadministered with warfarin.According to the experimental and clinical researches that have been published, the effects and the mechanisms of single traditional Chinese herbs and compound Chinese traditional medicine preparations on warfarin were reviewed and discussed in this paper, in order to provide reference for clinical rational drug use and related researches.

Key words: Traditional Chinese Medicine, warfarin, cytochrome p450, anticoagulant, drug interactions

CLC Number:

YIN Shuo, YU Yue, GUO Xing-lei, LIU Gao-feng. Effects of traditional Chinese medicine on the role of warfarin and the mechanisms[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(3): 327-334.

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