Effects of curcumin on VEGF and endostatin expression of Lewis lung carcinoma

Abstract

Abstract:

AIM: To investigate the effects of curcumin on vascular endothelial growth factor (VEGF) and endostatin expression in lung tumor tissues isolated from Lewis lung carcinoma. METHODS: Three groups were established: the control, the tumor model and the curcumin treatment. Ten C57BL/6 mice were assigned into the control group. Another 20 mice were subcutaneously injected with Lewis cells into the right limb armpit and were randomly divided into the model group and the curcumin group, ten in each. 20 mice of control and model groups were then administered intragastrically with 0.5% CMC-Na solution for 14 days, while mice of the treatment group received suspension of curcumin (100 mg/kg) solution by gavage for 14 days. Lung tumor tissues were isolated from each group after final administration. Weights of the mice and Lung tumor tissues were measured. VEGF and endostatin expression were analyzed by Western blot and Q-PCR. RESULTS: Weigts of lung tumor tissues reduced significantly. VEGF expression increased in lung tumor tissues, while endostatin expression decreased. CONCLUSION: Curcumin inhibits the development of lung tumor through down-regulating VEGF expression and up-regulating endostatin expression.

Key words: curcumin, vascular endothelial growth factor, endostatin

CLC Number:

R965.2

XU Buyuan, PAN Xiange, CHEN Chongbie, CAI Min, XU Lu. Effects of curcumin on VEGF and endostatin expression of Lewis lung carcinoma[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(2): 151-154.

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