Efficacy analysis of nimodipine in the treatment of acute severe brain injuries

Welcome to Chinese Journal of Clinical Pharmacology and Therapeutics,Today is Chinese

Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2002, Vol. 7 ›› Issue (2): 167-174.

Previous Articles Next Articles

Efficacy analysis of nimodipine in the treatment of acute severe brain injuries

LU Li-Hua, WU Nian-Zen, YANG Shang-Zhu

People's Hospital of He Country, He Country, Anhui 238200

Received:2001-06-11 Revised:2001-10-30 Online:2002-04-26 Published:2020-11-27

Abstract

Abstract: AIM: To observe the effect of nimodipine on the severe brain injury.METHODS: Nimodipine was ccsed for acute severe brain injury patients early in 6 hours after wounded.The effect and safety were observed in an open trial.RESULTS: The mortality and morbidity of 20 patients decreased significantly by the use of nimodipine in comparisom with another 20 patients treated normally.CONCLUSION: Nimodipine is benefit to severe brain injury patients.

Key words: severe traumatic head injury, nimodipine, brain

CLC Number:

R971

LU Li-Hua, WU Nian-Zen, YANG Shang-Zhu. Efficacy analysis of nimodipine in the treatment of acute severe brain injuries[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2002, 7(2): 167-174.

[1]	XU Wei, CHEN Feng, YE Zhijun. Effectss of hyperoside on traumatic brain injury rats by regulating RhoA/ROCK signaling pathway [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(4): 383-390.
[2]	YANG Sheng, WANG Deguo. Effects of sakubatril valsartan combined with dagliflozin in the treatment of patients with HFrEF and the effect on serum cTnⅠ and BNP levels [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(9): 1010-1015.
[3]	FAN Di, SHI Cuina, YANG Qingqing, JI Muhuo. Research progress on effects of sevoflurane anesthesia on developing brain [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(12): 1333-1339.
[4]	YANG Liu, LUO Ailin, LI Shiyong. Advance of general anesthetics-induced developing brain injury [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(12): 1381-1390.
[5]	PAN Rongrong, ZHI Yinghao, JIN Yongxi, ZHOU Xiahui. Influences of theaflavins on neuronal apoptosis and blood-brain barrier in rats with cerebral hemorrhage by regulating CaMKK2/AMPK signaling pathway [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(11): 1240-1246.
[6]	ZHONG Kailong, WANG Yongsheng, CHEN Fang, YE Yanrong. Exploration and expectation on treatment strategies of central nervous system diseases based on transporters at blood-brain barrier [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(8): 953-960.
[7]	ZHANG Gaojiao, WANG Xinxin, ZHOU Jia, WANG Leilei, DAI Qinxue. Ginsenoside Rb1 protects brain through Cav-1 for mice with cerebral ischemia-reperfusion injury [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(3): 265-270.
[8]	ZHOU Yancan. Effects of agomelatine on depressive disorder and brain-derived neurotrophic factor ZHOU Yancan [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(6): 699-703.
[9]	YAN Jieping，ZHANG Shuijun，ZHANG Guobing，HU Ying，LUO Dan，JIANG Hongjuan，LI Minjing. Protective effects of Butylphthalide on S-nitrosoglutathione-induced brain microvascular endothelial cells injury and potential mechanisms [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(5): 517-522.
[10]	GUAN Qiaobing, HAN Chenyang, CHU Zhiyuan, YANG Yi, ZHANG Xiaoling. Mechanism of butylphthalide activating cAMP/CREB/BDNF signaling to improve cognitive impairment after ischemia-reperfusion in mice [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(2): 152-157.
[11]	QIAO Yang, CHEN Qun, YANG Guang,CAO Yingya, LU Weihua. iTRAQ technology based differences of protein expression in sepsis-associated encephalopathy [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(11): 1269-1274.
[12]	SHAO Yaojun, ZHENG Tong,WANG Yanqiu,LIU Ling,YAO Yingshui. Nimodipine combined with flunarizine for preventing and treating migraine: A Meta-analysis [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(6): 646-652.
[13]	HAN Chenyang, ZHANG Xiaoling, GUAN Qiaobin, WANG Yanping. Effects of NBP on energy metabolism of human brain microvascular endothelial cells under the condition of glucose deprivation [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(12): 1329-1334.
[14]	WANG Shibiao, WANG Chengyi, WENG Bin, GUO Xiaofeng, LIN Hai. Comparison of the efficacy of non-invasive USCOM and milrinone in children with severe pneumonia and heart failure and its effect on brain natriuretic peptide levels [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(12): 1402-1407.
[15]	XU Hui，ZHANG Minyuan, DAI Qinxue. MiR-145 regulating SOD activity mediated brain protection of ginsenosides Rb1 in rats with cerebral ischemia-reperfusion injury [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(11): 1215-1220.

Efficacy analysis of nimodipine in the treatment of acute severe brain injuries

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments