Most Down Articles

Published in last 1 year | In last 2 years| In last 3 years| All| Most Downloaded in Recent Month | Most Downloaded in Recent Year|

Most Downloaded in Recent Year

Please wait a minute...


For Selected: Download Citations EndNote Ris BibTeX Toggle Thumbnails

Select

Dose conversion among different animals and healthy volunteers in pharmacological study HUANG Ji-Han,HUANG Xiao-Hui, CHEN Zhi-Yang, ZHENG Qing-Shan, SUN Rui-Yuan Chinese Journal of Clinical Pharmacology and Therapeutics    2004, 9 (9): 1069-1072.   Abstract （605）      PDF （152KB）（2259）       Knowledge map    Save In order to obtain equivalent dose, a dose conversion was important among different animals and healthy volunteers in preclinical pharmacology and I phase clinical trials. Body coefficient and standard weight were introduced into the formula to estimate the equivalent dose in this paper. Reference | Related Articles | Metrics

Select

Chinese Journal of Clinical Pharmacology and Therapeutics    1997, 2 (4): 295-298.   Abstract （63）      PDF （170KB）（1067）       Knowledge map    Save Reference | Related Articles | Metrics

Select

Chinese Journal of Clinical Pharmacology and Therapeutics    2000, 5 (2): 162-163.   Abstract （63）      PDF （74KB）（1449）       Knowledge map    Save Reference | Related Articles | Metrics

Select

Evaluation and calculation of the accumulation index in clinical pharmacokinetics LI Xian-xing, LI Lu-jin, XU Ling, ZHENG Qing-shan Chinese Journal of Clinical Pharmacology and Therapeutics    2013, 18 (1): 34-38.   Abstract （1001）      PDF （608KB）（1840）       Knowledge map    Save AIM: To analyze and evaluate the accumulation index (Rac) in clinical pharmacokinetics of multiple dosing administrations in order to obtain one reasonable method. METHODS: The plasma concentration-time data of arteether was simulated for 1000 subjects in multiple doses administration. The 20-40 subjects were sampled for 1000 time by the Boostrap method and values of Rac were calculated by the AUC, Cmax, Ctrough and model. The values of Rac were evaluated by their distributions. RESULTS: The AUC and Cmax method were more stable than the Ctrough and model method. If the efficacy or toxicity was related with the concentration, it was appropriate to use the Cmax method, and if the efficacy or toxicity was related with the time, it was appropriate to use the AUC method. CONCLUSION: The drug accumulation is related with effectiveness and safety, and the reasonable choice of Rac calculation method should be based on drug and data characteristics. Reference | Related Articles | Metrics

Select

Progress in research and evaluation on drug-plasma protein binding in pharmacology GUO Bin, LI Chuan Chinese Journal of Clinical Pharmacology and Therapeutics    2005, 10 (3): 241-253.   Abstract （257）      PDF （406KB）（1792）       Knowledge map    Save Drug-protein binding changes involved in numerous factors in vivo may cause changes of pharmacokinetic parameters.The tendency gained from large numbers of articles overemphasized the clinical importance of these changes.However, theoretic analysis and review of available literature data indicated that changes in plasma protein binding are usually of no principle pharmacodynamic implication.And they have little effect on the clinical exposure of a patient to a drug in a practical sense. The progress is reviewed in research and current opinions on drug-plasma protein binding in pharmacological basis for pharmacokinetic consequence and clinical relevance in this article. Reference | Related Articles | Metrics

Select

Analysis of metabolomic data: principal component analysis Jiye Aa Chinese Journal of Clinical Pharmacology and Therapeutics    2010, 15 (5): 481-489.   Abstract （728）      PDF （913KB）（1662）       Knowledge map    Save Metabolomics has been widely applied to life science and showing a promising perspective. Conventional statistic analysis is not applicable to the large, multivariate dataset generated by high-throughput metabolomic tool, while it's of crucial importance to analyze and interpret the dataset. This article reviews the basic methods of principal components analysis(PCA) that is popular in metabolomics study, aiming at strengthening the fundamental knowledge of PCA and standardizing the methods and procedures for data analysis. Reference | Related Articles | Metrics

Select

Chinese Journal of Clinical Pharmacology and Therapeutics    2001, 6 (2): 97-102.   Abstract （144）      PDF （195KB）（1649）       Knowledge map    Save Related Articles | Metrics

Select

The value and general consideration of pharmacometric study in new drug development LIU Dongyang,WANG Kun,MA Guangli,XIANG Xiaoqiang,LIU Jiang,ZHAO Ping,CHEN Rui,CHEN Yuancheng,HUANG Xiaohui, LI Li,LI Lujin,NIE Jing,WANG Yuzhu,WEI Chunmin,LU Wei,SHI Jun, ZHENG Qingshan Chinese Journal of Clinical Pharmacology and Therapeutics    DOI: 10.12092/j.issn.1009-2501.2018.09.001

Select

Progress in clinical application of topical anesthesia TAO Yijia, YANG Chun, LIU Cunming Chinese Journal of Clinical Pharmacology and Therapeutics    2023, 28 (5): 594-600.   DOI: 10.12092/j.issn.1009-2501.2023.05.015 Abstract （192）      PDF （614KB）（611）       Knowledge map    Save Topical anesthesia are being widely used in clinical diagnostic or therapeutic fields such as ophthalmology, ENT, dermatology, urology. It is defined as superficial loss of sensation in mucous membranes or skin, produced by direct application of penetrating local anesthetics. Topical anesthesia has the advantages of simple performance, high safety, quick recovery, which can effectively improve patient's satisfaction. In recent years, more and more attention has been paid to the concept of comfortable diagnosis and treatment. The new drugs and application methods of topical anesthesia are emerging constantly, special attention must be paid to their pharmacological characteristics and possible adverse reactions when using them. This article reviews the research progress of topical anesthesia in clinical application in order to provide reference for clinical practice. Related Articles | Metrics

Select

Sample size estimation in randomized controlled drug clinical trials LI Chan-juan, JIANG Zhi-wei, WANG Rui, XIA Jie-lai Chinese Journal of Clinical Pharmacology and Therapeutics    2011, 16 (10): 1132-1136.   Abstract （612）      PDF （223KB）（1327）       Knowledge map    Save Sample size estimation is a key research aspect in randomized controlled drug clinical trial. Sample size estimation factors, parameters and basic rules are discussed in our research. In addition, sample size estimation procedures are introduced based on two examples. A reference is provided for estimating sample size in randomized controlled clinical trials. Reference | Related Articles | Metrics

Select

Recent advancement in pharmacological effects of artemisinin and its derivatives GUO Yan, WANG Jun, CHEN Zheng-tang Chinese Journal of Clinical Pharmacology and Therapeutics    2006, 11 (6): 615-620.   Abstract （127）      PDF （207KB）（1181）       Knowledge map    Save Artemisinin, an active compound extracted from Artemisia annua, L.together with its derivatives are widely used as anti-malarial drugs.In recent years, artemisinin and many of its analogs were reported to possess some other effects such as anti-inflammatory, immuno-modulation and antitumor activities besides antiparasitic actions against Plasmodium falciparum and Schistosoma.Based on an introduction of the conventional actions and mechanisms of these drugs, we reviewed the recent progress of their new biological actions in this article. Reference | Related Articles | Metrics

Select

Advances in study of estrogen and its receptors signal transduction pathway FAN Guan-wei, HE Jun, WANG Hong, GAO Xiu-mei Chinese Journal of Clinical Pharmacology and Therapeutics    2007, 12 (3): 266-269.   Abstract （94）      PDF （155KB）（925）       Knowledge map    Save Estrogen gradually becomes the research hot spot because it has extensive biological effect, which exerts its function by binding to estrogen receptors (ERs).ERs have the widespread organization distribution, including the reproductive system, the skeleton and the cardiovascular system, and these provided the guarantee for the estrogen to display biology effect.This article reviews the advance of estrogen and its receptors signal transduction pathway in abroad and domestic. Reference | Related Articles | Metrics

Select

Advances on the study of the pharmacological effects of artemisinin and its derivatives LI Bin, ZHOU Hong Chinese Journal of Clinical Pharmacology and Therapeutics    2010, 15 (5): 572-576.   Abstract （107）      PDF （186KB）（1145）       Knowledge map    Save Artemisinin is a sesquiterpene lactone compounds, their derivatives include mainly dihydroartemisinin, artesunate, artemether and Artemisia ether. These drugs are now mainly used for clinical treatment of malaria. With the pharmacological action of artemisinin and its derivatives have been further studied, except antimalarial effects, researchers have found their anti-inflammatory, anti-sepsis, antitumor, radiosensitization, antimicrobial sensitivity, anti-fibrosis effects in recent years. Here, we collect and review the most newly pharmacological effects of artemisinin and its derivatives all over the world in past years. Reference | Related Articles | Metrics

Select

Research development between JNK pathway and apoptosis WEI Na, HE Hai-bo, ZHANG Chang-cheng, YUAN Ding, WANG Ting Chinese Journal of Clinical Pharmacology and Therapeutics    2013, 18 (7): 807-812.   Abstract （461）      PDF （261KB）（909）       Knowledge map    Save JNK pathway is closely associated with cell differentiation, apoptosis, stress response and many hunman diseases in the past 20 years, whose biochemical function, regulation under cell physiology and pathology are constantly noticed by domestic and foreign scholars. Recently, more research suggests that it plays an important role in regulating apoptosis, and it will be an important potential target for treatment of apoptosis-associated disease by regulating JNK signal pathway. In summary, the physiological and pathophysiological functions of JNK pathway and relation with apoptosis have been reviewed. Reference | Related Articles | Metrics

Select

Prediction of key pharmacokinetic parameters in human ZHU Jian-ping, SUN Jian-guo, PENG Ying, WANG Guang-ji Chinese Journal of Clinical Pharmacology and Therapeutics    2011, 16 (6): 699-709.   Abstract （630）      PDF （343KB）（1790）       Knowledge map    Save Volume of distribution, clearance, half of life and bioavailability are crucial pharmacokinetic parameters determining the extent and sustained time of drugs exposed in vivo. Thus, in the stage of drug discovery and development, it is of particular interest to estimate the pharmacokinetic parameters of drug candidates in human as early as possible to select the most promising compounds for further development. This paper reviews recent developments in prediction of human key pharmacokinetic parameters based upon preclinical animal pharmacokinetic data, absorption and metabolism data in vitro, physico-chemical property and in silico prediction. Reference | Related Articles | Metrics

Select

Chinese Journal of Clinical Pharmacology and Therapeutics    1998, 3 (2): 140-142.   Abstract （57）      PDF （112KB）（1015）       Knowledge map    Save Reference | Related Articles | Metrics

Select

Research progress of alopecia experimental model and its pharmacotherapeutics JIN Jianbo, ZHANG Jianhua Chinese Journal of Clinical Pharmacology and Therapeutics    2017, 22 (1): 115-120.   Abstract （430）      PDF （2893KB）（1182）       Knowledge map    Save Alopecia is a kind of disease characterized by loss of hair. Pathophysiological mechanism of alopecia and its hair regeneration therapy is the pressing issues of current study. The successful replication of Alopecia experimental model plays a key role in promoting the study of pathological mechanism and pharmacotherapeutics. This review systematically describes the progress in alopecia animal model and in vitro organ model, which have been established at home and abroad. Based upon the aforementioned experimental models, some relevant applications in experimental therapeutics are simultaneously enumerated. Hopefully all these information facilitate the researchers according to the need to select the appropriate model to carry out the experiment.  Reference | Related Articles | Metrics

Select

Discussion on dose and dosage regimen exploring and confirming in new drug clinical trials YANG Jin-bo Chinese Journal of Clinical Pharmacology and Therapeutics    2008, 13 (8): 841-846.   Abstract （173）      PDF （237KB）（1229）       Knowledge map    Save It is generally concerned by industries that some important questions in new drug clinical trials from designing the first dose in human to confirm the last dosage regimen, which is also one of the key bottlenecks to restrict the promotion of new drug research and development in China.Based on some references and review experience, this article is to discuss dose and dosage regimen exploring and confirming in new drug clinical trials. Reference | Related Articles | Metrics

Select

Blood pressure regulation of statins XIE Xiao-Jing, WANG An-Cai Chinese Journal of Clinical Pharmacology and Therapeutics    2004, 9 (4): 374-377.   Abstract （75）      PDF （158KB）（766）       Knowledge map    Save Statins is first choice of hypercholesteroiemia.Recently, clinical investigations have shown that statins can correct blood pressure in hypertension patients accompanied with lipid abnormalities.This result can be observed not only in untreated patients but also in patients treated with antihypertensive drugs.But some researches did not support this result completely.To some extend, the mechanisms responsible for the hypotensive effect seem to be largely independent on the effect of statins on lipid profile, and may be related to the improvement of endothelial function and the regulation of angiotensin II receptors. Reference | Related Articles | Metrics

Select

Research advances in models of hepatic and intestinal first-pass drug metabolism ZHU Jing, GUO Jian-jun, LIN Jun-hui, BU Hai-zhi, CHEN Xi-jing Chinese Journal of Clinical Pharmacology and Therapeutics    2012, 17 (8): 944-949.   Abstract （448）      PDF （269KB）（1141）       Knowledge map    Save Low oral bioavailability of a drug could be attributed to poor absorption and/or extensive first-pass metabolism.The liver and small intestine are the two most important organs for first-pass metabolism. In this review, the important drug-metabolizing enzymes located in the human liver and small intestine are introduced and the effects of different physiological structures of the two organs on overall first-pass metabolism are presented. Moreover, the research advances of the methods used to estimate hepatic and intestinal first-pass metabolism, such as in vitro, in situ, in vivo, in vitro-in vivo combined, knockout and transgenic models, are also summarized. Reference | Related Articles | Metrics

Select

Advances of the clinical pharmacology of hydroxychloroquine sulfate CUI Cheng, YAO Xueting, TU Siqi, XIE Jieen, LI Haiyan, LIU Dongyang Chinese Journal of Clinical Pharmacology and Therapeutics    2020, 25 (2): 221-226.   DOI: 10.12092/j.issn.1009-2501.2020.02.016 Abstract （626）      PDF （350KB）（1348）       Knowledge map    Save As the number of novel coronavirus disease (COVID-19) continues to increase, the medical situation is still critical, and potential therapeutic drugs, vaccines and stem cell replacement approaches are emerging. Chloroquine has shown better clinical antiviral efficacy than lopinavir/litonavir (clazidine) in clinical trials of small sample size. Since pharmacological action mechanism of hydroxychloroquine is similar with chloroquine and hydroxychloroquine is safer than chloroquine in the treatment of malaria and immunological diseases, the clinical pharmacology characteristics of hydroxychloroquine was reviewed, hoping to provide theoretical support for clinical effect verification of hydroxychloroquine from the perspective of clinical pharmacology and quantitative pharmacology. Related Articles | Metrics

Select

Chinese Journal of Clinical Pharmacology and Therapeutics    2001, 6 (4): 289-292.   Abstract （75）      PDF （137KB）（955）       Knowledge map    Save Reference | Related Articles | Metrics

Select

Overview and progress on the study of the pharmacokinetics of naringin ZHU Hong-ping, XIONG Yu-qing Chinese Journal of Clinical Pharmacology and Therapeutics    2013, 18 (11): 1297-1303.   Abstract （225）      PDF （306KB）（748）       Knowledge map    Save Naringin is a dihydroflavone compound with the function of promoting gastrointestinal motility, which was found in some Chinese medicine such as Fructus Aurantii, Fructus Aurantii Immaturus, Rhizoma Drynariae, Pummelo Peel and so on. Naringin's oral absorb was bad, extensive distributed in the body, and produced metabolin like p-hydroxybenzoic acid and p-hydroxycinnamic acid by the way of opening loop, dehydrogenation, splitting, then eliminated from the body. Naringin also could interact with other drugs with the inhibiton of some transporters and metabolic enzymes, then influenced the pharmacokinetics of other drugs. This text reviews the pharmacokinetics of naringin and it's influence on other drugs, then points out that the mechanism of interaction through the metabolic process and the influence of genetic polymorphism on its pharmacokinetics still need to be studied. Reference | Related Articles | Metrics

Select

Research progress of monoclonal antibodies in pharmacokinetic characteristics, analysis methods and method validation ZHU Xueya, LI Zeyun, TIAN Xin, ZHANG Xiaojian Chinese Journal of Clinical Pharmacology and Therapeutics    2021, 26 (1): 113-120.   DOI: 10.12092/j.issn.1009-2501.2021.01.015 Abstract （664）      PDF （459KB）（700）       Knowledge map    Save In recent years, monoclonal antibodies (mAbs) have been developing rapidly and widely used in fields of tumor, immunity, blood and other systemic diseases. Global share of mAbs in prescription drug market had reached up to $ 140 billion, 15.3% by 2019. As macromolecule proteins, with special structures and physiological properties, mAbs have great differences in absorption, distribution, metabolism and excretion in vivo compared with small molecule drugs, including characteristics of relatively large molecular mass, high specificity and selectivity in target combination, non-linear pharmacokinetics, time dependence, long half-life and so on. Fully understanding of these special pharmacokinetic characteristics shall effectively guide analysis of mAbs. Meanwhile, the particularity and complexity of disposal mechanism in organisms greatly increase the difficulty of biological detection. As a result, it is necessary to establish exclusive, sensitive, accurate and repeatable quantification methods in biological samples. This article focuses on pharmacokinetic characteristics, main analytical methods, and methodology validation of quantification for mAbs in biological samples, expounding with comparisons of small molecular drugs, so as to prompt development of pharmacokinetic study of this kind of drugs. Related Articles | Metrics

Select

Mouse models of type 2 diabetes mellitus LIU Qian, LI Xia-hui, ZHANG Xue-mei Chinese Journal of Clinical Pharmacology and Therapeutics    2013, 18 (10): 1196-1200.   Abstract （369）      PDF （825KB）（987）       Knowledge map    Save Type 2 diabetes was a disease influenced by genetic factors and environmental factors. Animal models of diatetes were essential tools for the understand of the pathogenesis、prevention and treatment of diabetes and its complications. Diabetes mouse models were normally classified into three classes which were spontaneously induced diabetes mouse, experimentally induced diabetes mouse and transgenic diabetes mouse. Each diabetes mouse only imitated clinical diabetes in some aspects and he characteristics of each model about mechanisms and physiology were described in this article. Researchers should choose the suitable diabetes mouse according to their research purpose. Reference | Related Articles | Metrics

Select

SPSS programs for blind review in drug clinical trials YANG Li-bo, GU Chun-hua Chinese Journal of Clinical Pharmacology and Therapeutics    2005, 10 (7): 836-840.   Abstract （64）      PDF （186KB）（489）       Knowledge map    Save This article discusses SYNTAX EDITOR' S actual application of SPSS 11.5 FOR WINDOWS for blind review in drug clinical trials with examples. The results show that applying SPSS software can deal with blind review easily, and produce corresponding report, get fast and exact result. Reference | Related Articles | Metrics

Select

Progress in research of phase Ⅱ metabolisms and their enzymes SHI Shu-ya, WANG Lian-sheng Chinese Journal of Clinical Pharmacology and Therapeutics    2014, 19 (1): 82-89.   Abstract （347）      PDF （326KB）（994）       Knowledge map    Save Phase Ⅱ drug-metabolizing reaction, characterized by the conjugation reaction, is an important way of body drug disposition. Glucuronidation, acetylation, methylation, glutathione conjugation reaction, and sulphation represent different conjugation reactions and are catalyzed by some similar genes or gene superfamily respectively. All these phase Ⅱ metabolic reactions have their own different characteristics and functional significance. Drug induced significant change of phase Ⅱ drug metabolizing enzyme activity may lead to clinical drug interactions. The genetic polymorphisms of phase Ⅱdrug metabolizing enzymes will affect the metabolism of endogenous substances, which may lead to the increased incidence of certain diseases, and these polymorphisms also affect the metabolism of exogenous substances, causing toxicity or changes in drug efficacy. Reference | Related Articles | Metrics

Select

Research progress in the treatment of depression with monome of Chinese herb, drug pairs, compound prescriptions and Chinese patent drugs CHEN Ying, YUAN Yonggui Chinese Journal of Clinical Pharmacology and Therapeutics    2021, 26 (5): 586-593.   DOI: 10.12092/j.issn.1009-2501.2021.05.016 Abstract （903）      PDF （536KB）（662）       Knowledge map    Save Depression is a relatively common psychosomatic disease in clinical practice. It is mainly characterized by significant and lasting depression. It generally manifests as depression, loss of interest, impaired cognitive function, etc. Some patients are accompanied by somatization symptoms such as insomnia or lethargy, Loss of appetite, fatigue, loss of libido, etc. In severe cases, self-injury or even suicide may occur. According to research, depression has become the third leading cause of disability and death. At present, the pathogenesis of depression has not been definitively concluded, but a large number of studies have shown that it is related to biochemical, neuroendocrine, and neuroimmunological factors. At present, selective 5-HT reuptake inhibitors are routinely used in clinical treatment, such as sertraline, citalopram, Prozac, etc., but they often have slow onset and obvious side effects, making it difficult to achieve satisfactory therapeutic effects. Traditional Chinese medicine has gradually begun to be accepted by doctors and patients in the treatment of refractory diseases due to its multi-component and multi-target characteristics. This article mainly discusses the research progress of Chinese herbal extracts, Chinese herbal medicine pairs, Chinese herbal compound prescriptions, and Chinese patent medicines in the treatment of depression, and provides references for the clinical application of Chinese medicines in the treatment of depression. Related Articles | Metrics

Select

Research advancement of heartleaf houttuynia herb on antibacterial action LI Juan, SHAO Hui, ZHONG Zheng-ling, CHU Ji-ru, XIE Hai-tang Chinese Journal of Clinical Pharmacology and Therapeutics    2012, 17 (12): 1427-1432.   Abstract （344）      PDF （249KB）（1107）       Knowledge map    Save Heartleaf houttuynia herb has many pharmacologic actions especially antibacterial action. This review describes the research advancement of heartleaf houttuynia herb on antibacterial action from three aspects including the whole antibacterial action evaluation, special antibacterial action, and the trouble in clinic and the study direction. This paper provides a review for the next research. Reference | Related Articles | Metrics

Select

Chinese Journal of Clinical Pharmacology and Therapeutics    2000, 5 (4): 344-348.   Abstract （57）      PDF （197KB）（1360）       Knowledge map    Save Reference | Related Articles | Metrics

Select

Study of the algorithm of elimination half-life time in pharmacokinetics CHEN Chao, XU Ling, ZHENG Qing-shan Chinese Journal of Clinical Pharmacology and Therapeutics    2013, 18 (8): 891-896.   Abstract （472）      PDF （1216KB）（1010）       Knowledge map    Save AIM: To study a reasonable algorithm of terminal half-life time (t1/2z) in pharmacokinetics by the accuracy and precision.METHODS: The plasma concentration-time data of pu- erarin was simulated for 1000 subjects by using parameters of intravenous two-compartment models in the variations of 15%, 25% and 35%. Resampling 15, 25, 35, and 45 from the 1000 subjects were used to calculate t1/2z by 4-point, 5-point, 6-point, all-point methods when there were different points in eliminate phase. The results of these methods were compared to the true value and expressed by accuracy and precision.RESULTS: The 5-point method can provide a t1/2z with better accuracy and precision when there are four concentration points in eliminate phase, the 4-point method provide the one with better accuracy in three points in eliminate phase, 6-point method provide t1/2z with better precision in both three and four points in eliminate phase. There is no reasonable t1/2z in all four methods if there are two points in eliminate phase.CONCLUSION: Three concentration points should be at least included in eliminating phase for calculating a t1/2z which is usually more reasonable in 4-points or 5-points method. Reference | Related Articles | Metrics

Select

Internationally agreed medical terminology :Medical Dictionary for Regulatory Activities BO Qing-yan, XIONG Ning-ning, ZOU Jian-dong, JIANG Meng, LIU Fang, Anna Zhao-Wong Chinese Journal of Clinical Pharmacology and Therapeutics    2007, 12 (5): 586-590.   Abstract （283）      PDF （201KB）（1094）       Knowledge map    Save The Medical Dictionary for Regulatory Activities (MedDRA) was developed under the auspices of International Conference on Harmonisation (ICH). It is the standard terminology use by regulators and the biopharmaceutical industry through all phases of clinical development and in the post-marketing arena. The terminology supports the coding, retrieval, and analysis of a variety of clinical data, including adverse events, edicaland social history, indications and investigations. This Reference | Related Articles | Metrics

Select

Comparison of medical abortion, induced abort ion and medical with induced abortion in the termination of early pregnancy XU Lan, ZHANG Yong-Feng, ZHENG Yan-Luan Chinese Journal of Clinical Pharmacology and Therapeutics    2000, 5 (4): 340-343.   Abstract （108）      PDF （165KB）（584）       Knowledge map    Save Aim To compare the advantage of different methods of terminating early pregnancy. Methods 684 women in early pregnancy(≤49 d)were allocated into three groups according to their request:Group A (medical abortion, n=241), taking (po)mifepristone 25 mg every 12 h for three days and then taking misopostol 600 μg at 8:00 on the forthday;Group B (induced abortion, n=220), taking the routine intrauterine operation by vacuum aspirator and Group C (medical with induced abortion, n=223), inserting a Gongshuan suppository into rectum 0.5 ~ 2 h before induced abortion operation.Some indices w ere compared, including the efficacy, vaginal bleeding volume and time, side effects and acceptability of the three abortion methods.Results The abortion effects of Group C and B are better than that of Group A (P<0.01).The vaginal bleeding volume of Group C is the least, then is the Group B, and the last is Group A (P<0.01).The vaginal bleeding time of Group B and C is apparently shorter than that of Group A (P<0.01).The infection rate after abortion operation of Group B and C is lower, compared with Group A (P<0.01, P<0.05).The acceptability rate of medical with induced abort ion is higher than that of the other two groups (P<0.01).Conclusion The medical with induced abortion is a safe, fast, less painful and less side effects approach to terminate early pregnancy, and it is easily accepted by patients. Reference | Related Articles | Metrics

Select

Comparative study on effects of active ingredients of several traditional Chinese medicines on rabbit platelet aggregation in vitro WU Yuan, GUO Hong-bao, WANG Tie-jun, WANG Yin-ye Chinese Journal of Clinical Pharmacology and Therapeutics    2007, 12 (9): 1047-1051.   Abstract （88）      PDF （183KB）（611）       Knowledge map    Save AIM: To compare the inhibitory activities of the active ingredients of several traditional Chinese medicines on platelet aggregation.METHODS: The platelet aggregation was tested with Born's method, which was induced by ADP, PAF and collagen.The effects on platelet aggregation of six ingredients were evaluated to determine their characteristics.RESULTS: Ginsenosides, panax notoginosides and safflor pigment showed significant inhibitory effects on the aggregation induced by the three drugs;ginsenosides showed the most potent inhibitory activity among them.Salvianolic acids and pueraria flavonoids evidently inhibited the aggregation induced by ADP or collagen, but did not influence PAF-induced platelet aggregation.Ophiopogon japonicus saponins significantly inhibited collagen-induced platelet aggregation, but did not obviously inhibit the aggregation induced by ADP or PAF.CONCLUSION: Ginsenosides showed the most potent inhibitory effect on platelet aggregation among these ingredinents.Panax notoginosides, ginsenosides and safflor pigment displayed extensive inhibitory activities on platelet aggregation.These results provide more information for the clinical selection of Chinese materia medica in the treatment of thrombotic diseases and the development of new Chinese medicine. Reference | Related Articles | Metrics

Select

Pharmacology progress on the main bioactive components of Ligusticum chuanxiong hort LI Haigang, HU Shaiping, ZHOU Yi, XU Dandan, MA Ning, TANG Jing, BAO Meihua, ZHENG Xiahui Chinese Journal of Clinical Pharmacology and Therapeutics    2018, 23 (11): 1302-1308.   DOI: 10.12092/j.issn.1009-2501.2018.11.018 Abstract （798）      PDF （3254KB）（865）       Knowledge map    Save Ligusticum chuanxiong hort contains more than 100 kinds of pharmacological active ingredients. This study summarized its main bioactive components in pharmacology progress based on pharmacokinetics, and explained the pharmacokinetics and pharmacodynamics of ferulic acid, ligustilide, senkyunolide A, senkyunolide I and tetramethylpyrazine in detail. It will provide some new ideas and methods to the clinical application, deep development and utilization of Ligusticum chuanxiong hort. Reference | Related Articles | Metrics

Select

Study on pharmacokinetics of rosuvastatin and its drug interactions with other drugs WEN Jin-hua, XIONG Yu-qing Chinese Journal of Clinical Pharmacology and Therapeutics    2011, 16 (11): 1309-1314.   Abstract （515）      PDF （261KB）（822）       Knowledge map    Save Rosuvastatin, a new generation of statins , has better liver selectivity, less metabolism and long elimination half-life.It has more lipid-lowering effect and a wide range prospects of clinical applications. Moreover, rosuvastatin has good tolerability and the incidence of adverse reactions was similar to other kind of statins. In this paper, rosuvastatin pharmacokinetics and pharmacokinetic interactions with other drugs are reviewed. In order to lay down a solid theory foundation for the guidance in clinical usage of Rosuvastatin, ensure the safety and effectiveness of clinical usage, achieving individualized therapy in its true sense. Reference | Related Articles | Metrics

Select

Statistical considerations of group sequential design in oncology clinical trials GUO Yang, JIANG Zhi-wei, XIA Jie-lai, WANG Yu-kun Chinese Journal of Clinical Pharmacology and Therapeutics    2013, 18 (2): 175-180.   Abstract （769）      PDF （729KB）（1133）       Knowledge map    Save The group sequential design is a good choice of oncology trial design because of the smaller sample size and the probability of early stopping for efficacy/futility. To design and apply the group sequential trials scientifically, we illustrate how to choose the number, timing of interim analysis, alpha spending function and optimal trial parameters by employing Monte Carlo simulation. The simulation results show that the three-stage design of 2∶1∶1 time point, whose expected sample size is 420.53, is the best choice in the group sequential design. And the expect sample size is only 420.53. Among the five α spending functions proposed by Lan and DeMets, the 1.5th power and quadratic α spending function, which have the smallest expect sample size of 393 cases, are better than O'Brien-Fleming and Pocock design. Reference | Related Articles | Metrics

Select

Advances in study of CYP2B6 gene polymorphisms and its functional significances QIN Wen-jie, ZHOU Hong-hao Chinese Journal of Clinical Pharmacology and Therapeutics    2008, 13 (12): 1434-1440.   Abstract （158）      PDF （228KB）（758）       Knowledge map    Save CYP2B6 is an important cytochrome P450 enzymes and contributes to metabolism of about 7 % of therapeutically usual drugs, including somewith narrow therapeutic index.The human CYP2B6 gene is highly polymorphic, having many single nucleotide polymorphisms in promoters and coding regions.To date, at least 29 CYP2B6 alleles have been identified. This review summarizes recent advances in the study of CYP2B6 about gene polymorphism, the frequency of CYP2B6 alleles among different populations, and their clincal significance. Reference | Related Articles | Metrics

Select

Progress in studies of reproductive toxicity of solanine ZHOU Guo-liang, SONG Yi-sheng, XIN Yan-fei, XUAN Yao-xian Chinese Journal of Clinical Pharmacology and Therapeutics    2013, 18 (11): 1291-1296.   Abstract （257）      PDF （268KB）（646）       Knowledge map    Save Solanine is widely distributed in potatoes, tomatoes and eggplant and other solanaceous plants. It causes widespread concern for anti-tumor and potential toxic effects. This paper reviewed the research progress in the reproductive toxicity studies of solanine. Reference | Related Articles | Metrics

Select

Research progress on the pharmacokinetic profile of borneol TENG Yi, YANG Hai-ling Chinese Journal of Clinical Pharmacology and Therapeutics    2015, 20 (4): 469-475.   Abstract （270）      PDF （261KB）（969）       Knowledge map    Save In recent years, the research for their own properties of borneol and its impact on the rest of the drug in vivo is more. Therefore, it is necessary to summarize the research of borneol in recent years. This paper reviews the progress of borneol and promote other drug on absorption, distribution, metabolism and excretion of pharmacokinetic aspects. The results showed that the borneol can change the blood brain barrier (BBB) ,cornea, skin and other mucous membrane structure, and to promote other drugs through these structures to reach the site of action. But the study of metabolism of borneol is still inadequate,in synthetic borneol is vented or prototype components to be converted into camphor discharge are divided on the issue. More serious problem is that a lot of research ignores the composition owing to the different varieties of characteristics of borneol, making it is impossible to refer to each other, and even inconsistencies between the various research results. These problems are to be solved. Reference | Related Articles | Metrics